VCAN

Across TCGA patient cohorts, VCAN mutation is significantly associated with the RNA expression of many other genes, with 9,121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCAN-associated genes across cancer lineages are CIDECP1, OIP5, and EZH2. Each is linked with VCAN in more than 5 cancer types. Because this analysis shows association rather than direction, both VCAN-to-partner and partner-to-VCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CIDECP1 grouped by VCAN-low versus VCAN-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAN→partner) and Y-score (partner→VCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CIDECP1 →	+0.448	+3.188	<.001	.009	3	6
STAD	OIP5 →	+0.840	+2.618	<.001	<.001	3	6
STAD	EZH2 →	+0.649	+2.584	<.001	<.001	3	6
STAD	KIF20A →	+0.523	+1.874	.005	.002	3	6
STAD	CCNB1 →	+0.810	+2.584	<.001	<.001	3	6
STAD	H2AZ1 →	+0.541	+4.033	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,121 associations by consensus.

CIDECP1 by VCAN expression — READ

Explore this box plot interactively →