VCAN

Across TCGA pan-cancer cohorts, VCAN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VCAN data layer compared with 12 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VCAN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VCAN expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

MESO, STAD, and UVM are the cancer types where VCAN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.363	0.676	<.001	104	view →
STAD	OS	Median	All	0.303	0.542	<.001	84	view →
UVM	DFS	Quartile	II,III,IV	0.333	0.703	.003	77	view →
UCS	DFS	Median	IV	0.952	0.367	.001	50	view →
BLCA	OS	Quartile	All	0.357	0.733	.001	37	view →
LGG	OS	Median	All	0.938	0.831	<.001	30	view →
ACC	DFS	Quartile	All	0.206	0.671	.004	24	view →
CESC	DFS	Tertile	All	0.738	0.850	.007	22	view →
KICH	OS	Quartile	All	0.754	1.000	.026	19	view →
GBM	DFS	Tertile	All	0.493	0.208	.002	15	view →
LAML	DFS	Median	All	0.427	0.697	.006	12	view →
HNSC	OS	Tertile	III,IV	0.557	0.775	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VCAN–MESO (OS)

Open the MESO breakdown →