VCAN

Across TCGA patient cohorts, VCAN mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCAN-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with VCAN in more than 6 cancer types. Because this analysis shows association rather than direction, both VCAN-to-partner and partner-to-VCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by VCAN-low versus VCAN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAN→partner) and Y-score (partner→VCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.294	+1.765	.003	.012	3	7
COAD	Caspase-7-cleavedD198 →	+0.809	+2.239	<.001	.004	3	7
UCEC	Cyclin-B1 →	+0.537	+2.137	<.001	<.001	3	6
COAD	MYH11 →	-0.755	-1.584	.039	.016	3	6
STAD	FoxM1 →	+0.248	+1.616	.005	.038	3	5
LUAD	Caveolin-1 →	-0.717	-2.247	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

4E-BP1 by VCAN expression — STAD

Explore this box plot interactively →