VCAN

Across TCGA cell cohorts, VCAN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,793 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VCAN-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Positive regulation of supramolecular fiber organization, and Regulation of focal adhesion assembly. Each is linked with VCAN in more than 10 cancer types. Because this analysis shows association rather than direction, both VCAN-to-partner and partner-to-VCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by VCAN-low versus VCAN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAN→partner) and Y-score (partner→VCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.126	+3.171	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of supramolecular fiber organization →	+0.089	+2.833	<.001	.008	3	11
BONE	Regulation of focal adhesion assembly →	+0.126	+3.171	<.001	<.001	3	11
BONE	Regulation of cell-substrate adhesion →	+0.107	+2.919	<.001	<.001	3	10
BONE	Endosomal transport →	+0.068	+3.751	<.001	<.001	3	10
BONE	Viral process →	+0.113	+4.112	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,793 associations by consensus.

Regulation of cell-substrate junction assembly by VCAN expression — BONE

Explore this box plot interactively →