VCAN

Across TCGA cell cohorts, VCAN mutation is significantly associated with the RNA expression of many other genes, with 1,187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VCAN-associated genes across cancer lineages are TMEM170A, CCNF, and ARSK. Each is linked with VCAN in more than 4 cancer types. Because this analysis shows association rather than direction, both VCAN-to-partner and partner-to-VCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM170A grouped by VCAN-low versus VCAN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAN→partner) and Y-score (partner→VCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM170A →	+0.467	+2.459	.003	.006	3	5
BLOOD_Leukemia	CCNF →	+0.620	+3.380	.002	.001	3	4
LUNG_NSCLC_LUAD	ARSK →	+0.402	+2.459	.007	.008	3	4
STOMACH	C1QBP →	+0.651	+3.529	.003	<.001	3	3
STOMACH	CENPE →	+0.865	+2.392	.002	.006	3	3
STOMACH	DCK →	+0.664	+3.137	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,187 associations by consensus.

TMEM170A by VCAN expression — LARGE_INTESTINE

Explore this box plot interactively →