VAX1

Across TCGA patient cohorts, VAX1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAX1-associated genes across cancer lineages are INPP4B, PKC-b-II_pS660, and ATM. Each is linked with VAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX1-to-partner and partner-to-VAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by VAX1-low versus VAX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX1→partner) and Y-score (partner→VAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.532	-3.161	.003	.019	3	2
COAD	PKC-b-II_pS660 →	-0.425	-3.161	.015	.019	3	2
COAD	ATM →	-0.604	-3.161	.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.246	-1.925	.006	.005	3	2
UCEC	p90 RSK_pT359_S363 →	-0.147	-2.000	.043	.029	3	2
UCEC	Annexin-1 →	+0.601	+3.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

INPP4B by VAX1 expression — COAD

Explore this box plot interactively →