VAX1

Across TCGA cell cohorts, VAX1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VAX1-associated genes across cancer lineages are OR5P3, FAM9A, and IZUMO3. Each is linked with VAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX1-to-partner and partner-to-VAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5P3 grouped by VAX1-low versus VAX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX1→partner) and Y-score (partner→VAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR5P3 →	+0.125	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	IZUMO3 →	+0.073	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR5P3 by VAX1 expression — BLOOD_Leukemia

Explore this box plot interactively →