VAV3-AS1

Across TCGA pan-cancer cohorts, VAV3-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of VAV3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where VAV3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types VAV3-AS1 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, BRCA, and KICH are the cancer types where VAV3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAV3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.217	<.001	7	view →
BRCA	All	All	+0.321	<.001	6	view →
KICH	All	All	−0.176	<.001	5	view →
BLCA	All	All	−0.138	.023	3	view →
KIRC	Male	All	−0.059	.024	3	view →
THCA	Male	All	−0.476	.002	1	view →
ESCA	All	All	−0.195	.041	1	view →
COAD	Female	All	−0.075	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

VAV3-AS1–LUSC

Open the LUSC breakdown →