VAV2

Across TCGA patient cohorts, VAV2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,970 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VAV2-associated genes across cancer lineages are SURF4, PTPA, and DOLPP1. Each is linked with VAV2 in more than 6 cancer types. Because this analysis shows association rather than direction, both VAV2-to-partner and partner-to-VAV2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VAV2 versus SURF4 in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV2→partner) and Y-score (partner→VAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SURF4 →	+0.731	+0.315	<.001	<.001	3	7
UCEC	PTPA →	+1.027	+0.377	<.001	<.001	3	6
UCEC	DOLPP1 →	+0.646	+0.298	<.001	<.001	3	6
UCEC	SSNA1 →	+1.678	+0.361	<.001	<.001	3	6
UCEC	TMEM250 →	+0.880	+0.349	<.001	<.001	3	6
OV	TOR1B →	+0.490	+0.426	.004	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,970 associations by consensus.

VAV2 vs SURF4 — UCEC

Explore this scatter interactively →