VAV2

Across TCGA pan-cancer cohorts, VAV2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VAV2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VAV2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VAV2 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, STAD, and COAD are the cancer types where VAV2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAV2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.132	<.001	12	view →
STAD	Male	II,III,IV	+2.217	<.001	9	view →
COAD	All	II,III,IV	+0.535	<.001	8	view →
BLCA	All	III,IV	+1.256	<.001	7	view →
THCA	Male	All	−0.450	<.001	7	view →
BRCA	All	III,IV	+1.100	<.001	6	view →
LUAD	All	II,III,IV	+0.529	.001	6	view →
KIRC	Male	II,III,IV	−0.511	<.001	6	view →
ESCA	All	All	+1.591	.010	4	view →
LIHC	All	All	+0.260	.030	3	view →
CHOL	All	All	+0.804	.008	2	view →
PRAD	All	All	+0.705	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VAV2–HNSC

Open the HNSC breakdown →