VAV2

Across TCGA patient cohorts, VAV2 mutation is significantly associated with the RNA expression of many other genes, with 2,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAV2-associated genes across cancer lineages are BNIP3P1, MLLT10P2, and SFXN1. Each is linked with VAV2 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAV2-to-partner and partner-to-VAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P1 grouped by VAV2-low versus VAV2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV2→partner) and Y-score (partner→VAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P1 →	+0.366	+2.617	<.001	<.001	3	3
KIRC	MLLT10P2 →	+0.210	+6.081	<.001	.002	3	3
UCEC	SFXN1 →	+0.462	+2.828	<.001	<.001	3	3
GBM	RPL7AP69 →	+0.121	+4.370	<.001	.006	3	2
GBM	PPP1R26P4 →	+0.019	+4.459	.001	.005	3	2
UCEC	RNA5SP422 →	+0.403	+1.448	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,866 associations by consensus.

BNIP3P1 by VAV2 expression — UCEC

Explore this box plot interactively →