VAV2

Across TCGA cell cohorts, VAV2 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VAV2-associated genes across cancer lineages are PPIAL4F, GUCA2B, and SH3GL2. Each is linked with VAV2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAV2-to-partner and partner-to-VAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by VAV2-low versus VAV2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV2→partner) and Y-score (partner→VAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPIAL4F →	+0.060	+3.832	.001	.005	3	1
CNS	GUCA2B →	+0.047	+4.566	<.001	.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.444	+3.474	<.001	.003	3	1
LARGE_INTESTINE	CLPSL1 →	+0.098	+2.791	.001	.005	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

PPIAL4F by VAV2 expression — CNS

Explore this box plot interactively →