VAV2

Across TCGA cell cohorts, VAV2 mutation is significantly associated with the mutation status of many other genes, with 4,845 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAV2-associated genes across cancer lineages are GAREM1, ADGRG7, and ADAMTS19. Each is linked with VAV2 in more than 3 cancer types. Because this analysis shows association rather than direction, both VAV2-to-partner and partner-to-VAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAREM1 grouped by VAV2-low versus VAV2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV2→partner) and Y-score (partner→VAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GAREM1 →	+4.922	+3.584	.001	.001	1	4
BLOOD_Leukemia	ADGRG7 →	+3.375	+2.728	.003	.003	1	4
OVARY	ADAMTS19 →	+4.217	+4.217	.001	.001	1	4
BLOOD_Leukemia	KCNA6 →	+3.375	+2.728	.003	.003	1	4
OVARY	DEPDC5 →	+4.217	+4.217	.001	.001	1	4
LARGE_INTESTINE	LRFN1 →	+2.000	+2.662	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,845 associations by consensus.

GAREM1 by VAV2 expression — BLOOD_Lymphoma

Explore this box plot interactively →