VAT1L

Across TCGA patient cohorts, VAT1L mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAT1L-associated genes across cancer lineages are PKC-a, Annexin_VII, and VHL. Each is linked with VAT1L in more than 1 cancer types. Because this analysis shows association rather than direction, both VAT1L-to-partner and partner-to-VAT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a grouped by VAT1L-low versus VAT1L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAT1L→partner) and Y-score (partner→VAT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a →	-0.381	-3.000	.012	.034	3	2
SKCM	Annexin_VII →	+0.124	+1.874	.026	.049	3	2
UCEC	VHL →	-0.671	-1.584	.006	.019	3	2
SKCM	BRCA2 →	-0.147	-2.999	.027	.030	3	2
COAD	ATM →	-0.683	-3.161	<.001	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.671	+3.016	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PKC-a by VAT1L expression — SKCM

Explore this box plot interactively →