VASP

Across TCGA pan-cancer cohorts, VASP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VASP data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VASP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VASP expression acts as an unfavorable survival marker, although some lineages such as OV and CCRCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where VASP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.431	0.764	.006	22	view →
PDAC	DFS	Tertile	IV	0.228	0.934	.024	9	view →
LSCC	OS	Quartile	II,III,IV	0.647	1.000	.012	9	view →
OV	DFS	Quartile	All	0.884	0.459	.035	8	view →
GBM	DFS	Tertile	All	0.638	0.790	.021	3	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	2	view →
LUAD	OS	Median	II,III,IV	0.900	0.963	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VASP–HNSC (DFS)

Open the HNSC breakdown →