VASP

Across TCGA pan-cancer cohorts, VASP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of VASP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VASP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VASP is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where VASP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VASP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.022	<.001	12	view →
HNSC	Male	All	+1.171	<.001	11	view →
THCA	Male	III,IV	+0.995	<.001	11	view →
KICH	Male	II,III,IV	−1.386	<.001	9	view →
LIHC	Female	II,III,IV	+1.243	<.001	9	view →
KIRP	All	III,IV	+0.758	.003	8	view →
BRCA	All	All	+0.436	<.001	6	view →
CHOL	Male	All	+3.081	<.001	5	view →
STAD	Male	All	+0.668	.001	5	view →
LUSC	Female	All	−0.615	<.001	5	view →
COAD	All	All	−0.247	.001	5	view →
BLCA	Male	All	−0.753	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

VASP–KIRC

Open the KIRC breakdown →