VASP

Across TCGA cell cohorts, VASP mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VASP-associated genes across cancer lineages are MT4, OBP2A, and MSGN1. Each is linked with VASP in more than 1 cancer types. Because this analysis shows association rather than direction, both VASP-to-partner and partner-to-VASP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by VASP-low versus VASP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VASP→partner) and Y-score (partner→VASP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MT4 →	+3.830	+3.556	<.001	.007	3	1
LARGE_INTESTINE	OBP2A →	+0.132	+3.878	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CPLX4 →	+0.021	+3.766	.006	.004	3	1
LARGE_INTESTINE	S100G →	+1.372	+3.688	<.001	.002	3	1
LARGE_INTESTINE	INSL5 →	+0.191	+3.626	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MT4 by VASP expression — LARGE_INTESTINE

Explore this box plot interactively →