VASH1

Across TCGA patient cohorts, VASH1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VASH1-associated genes across cancer lineages are PCNA, S6_pS240_S244, and ATM. Each is linked with VASH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VASH1-to-partner and partner-to-VASH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by VASH1-low versus VASH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VASH1→partner) and Y-score (partner→VASH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.252	+2.459	.009	.019	3	2
UCEC	S6_pS240_S244 →	+0.462	+2.000	.011	.032	3	2
UCEC	ATM →	-0.665	-2.700	.001	.006	3	2
UCEC	Fibronectin →	-0.414	-3.160	.005	.019	3	1
UCEC	HSP70 →	-0.371	-2.000	.040	.032	3	1
UCEC	ACVRL1 →	-0.181	-2.000	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PCNA by VASH1 expression — UCEC

Explore this box plot interactively →