VASH1

Across TCGA pan-cancer cohorts, VASH1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VASH1 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher VASH1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VASH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

ACC, HNSC, and UVM are the cancer types where VASH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.279	0.636	<.001	120	view →
HNSC	DFS	Median	All	0.382	0.249	<.001	100	view →
UVM	DFS	Median	All	0.413	0.758	<.001	97	view →
KIRC	OS	Tertile	All	0.761	0.594	<.001	80	view →
UCS	DFS	Median	IV	0.952	0.367	.001	72	view →
PAAD	OS	Median	All	0.704	0.521	<.001	52	view →
LUSC	DFS	Tertile	III,IV	0.381	1.000	.009	35	view →
SKCM	OS	Quartile	II,III,IV	0.454	0.247	.003	34	view →
LGG	OS	Median	All	0.751	0.866	<.001	26	view →
PRAD	DFS	Tertile	All	0.821	0.916	.008	18	view →
LAML	DFS	Tertile	All	0.248	0.459	.023	16	view →
DLBC	DFS	Median	III,IV	1.000	0.146	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VASH1–ACC (DFS)

Open the ACC breakdown →