Across TCGA patient cohorts, VARS1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,217 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible VARS1-associated genes across cancer lineages are WDR46, GALNT16, and NECAB2. Each is linked with VARS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both VARS1-to-partner and partner-to-VARS1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS1→partner) and Y-score (partner→VARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR46 →	+0.422	+0.225	<.001	<.001	3	5
BRCA	GALNT16 →	-1.126	-0.321	<.001	<.001	3	4
GBM	NECAB2 →	-0.739	-0.126	.005	.006	3	4
GBM	SYT7 →	-1.015	-0.165	.008	.006	3	4
BRCA	MAN1C1 →	-0.638	-0.187	<.001	<.001	3	4
OV	FBXW2 →	-0.429	-0.185	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,217 associations by consensus.

Exploration

VARS1 survival (RNA) · tumor vs normal (RNA) · all VARS1 data types