VAMP8

Across TCGA pan-cancer cohorts, VAMP8 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated VAMP8 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher VAMP8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated VAMP8 expression acts as an unfavorable survival marker, although some lineages such as THCA and MESO show a favorable association.

THCA, MESO, and HNSC are the cancer types where VAMP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.985	0.891	.001	67	view →
MESO	DFS	Tertile	All	0.533	0.298	.003	57	view →
HNSC	DFS	Tertile	IV	0.212	0.372	.001	48	view →
LGG	OS	Median	All	0.358	0.536	<.001	45	view →
KIRC	DFS	Tertile	II,III,IV	0.628	0.388	.003	35	view →
LUSC	DFS	Median	III,IV	0.908	0.520	.008	16	view →
LIHC	OS	Median	III,IV	0.216	0.563	.007	16	view →
BLCA	DFS	Tertile	All	0.548	0.420	.012	12	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	12	view →
KICH	OS	Quartile	II,III,IV	0.679	1.000	.017	12	view →
UCS	OS	Quartile	III,IV	0.339	0.606	.027	12	view →
READ	OS	Quartile	IV	0.435	1.000	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

VAMP8–THCA (OS)

Open the THCA breakdown →