VAMP8

Across TCGA pan-cancer cohorts, VAMP8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VAMP8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where VAMP8 RNA is repressed in tumor relative to normal tissue. In most cancer types VAMP8 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, THCA, and BRCA are the cancer types where VAMP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAMP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.315	<.001	11	view →
THCA	All	II,III,IV	+0.612	<.001	8	view →
BRCA	All	III,IV	+1.189	<.001	6	view →
KIRC	All	All	+0.232	.002	6	view →
CHOL	All	All	+1.541	<.001	5	view →
LUSC	All	II,III,IV	−0.612	<.001	5	view →
COAD	Female	All	−0.610	<.001	5	view →
LIHC	All	All	+0.359	.002	5	view →
BLCA	All	IV	+2.198	.013	4	view →
UCEC	All	All	+1.506	<.001	4	view →
READ	All	III,IV	−1.005	.011	3	view →
ESCA	All	All	+0.757	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VAMP8–KICH

Open the KICH breakdown →