VAMP8

Across TCGA pan-cancer cohorts, VAMP8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VAMP8 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VAMP8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAMP8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where VAMP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.303	0.589	.004	14	view →
GBM	OS	Quartile	All	0.241	0.582	.004	4	view →
LSCC	OS	Median	III,IV	0.446	0.834	.029	4	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.871	.030	3	view →
HNSC	DFS	Tertile	All	0.799	0.598	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VAMP8–PDAC (DFS)

Open the PDAC breakdown →