VAMP7

Across TCGA pan-cancer cohorts, VAMP7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VAMP7 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VAMP7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAMP7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where VAMP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.235	0.657	.007	20	view →
GBM	OS	Median	All	0.405	0.675	<.001	18	view →
PDAC	OS	Median	All	0.441	0.698	.003	18	view →
LUAD	OS	Quartile	III,IV	1.000	0.280	.013	15	view →
HNSC	DFS	Quartile	All	0.160	0.947	.045	12	view →
LSCC	OS	Quartile	III,IV	0.902	0.522	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VAMP7–CCRCC (DFS)

Open the CCRCC breakdown →