VAMP7

Across TCGA pan-cancer cohorts, VAMP7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VAMP7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VAMP7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VAMP7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where VAMP7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAMP7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.769	<.001	11	view →
LIHC	Male	All	+1.086	<.001	8	view →
KIRC	Male	III,IV	−0.476	<.001	8	view →
STAD	All	II,III,IV	+0.745	<.001	7	view →
KICH	Female	All	−0.942	<.001	6	view →
BLCA	All	III,IV	+0.473	.013	6	view →
BRCA	All	II,III,IV	+0.294	<.001	6	view →
THCA	All	All	−0.246	.003	6	view →
CHOL	Female	All	+0.903	.011	2	view →
ESCA	All	All	+0.751	.001	2	view →
KIRP	Male	All	−0.437	.008	2	view →
LUAD	Male	II,III,IV	+0.315	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VAMP7–HNSC

Open the HNSC breakdown →