VAMP3

Across TCGA pan-cancer cohorts, VAMP3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of VAMP3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where VAMP3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VAMP3 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

PDAC, LUAD, and COAD are the cancer types where VAMP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAMP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+1.271	<.001	9	view →
LUAD	Female	II,III,IV	−0.451	<.001	9	view →
COAD	Male	III,IV	−0.291	<.001	9	view →
CCRCC	Female	All	+0.251	<.001	9	view →
LSCC	Male	All	−0.510	<.001	8	view →
OV	All	All	−0.542	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

VAMP3–PDAC

Open the PDAC breakdown →