VAMP3

Across TCGA pan-cancer cohorts, VAMP3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VAMP3 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VAMP3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated VAMP3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

KIRC, ACC, and LGG are the cancer types where VAMP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.746	0.519	<.001	91	view →
ACC	OS	Median	All	0.796	0.947	.001	66	view →
LGG	DFS	Tertile	All	0.657	0.832	<.001	51	view →
PAAD	OS	Tertile	All	0.265	0.646	<.001	49	view →
COAD	DFS	Tertile	All	0.869	0.721	.004	37	view →
BLCA	DFS	Median	All	0.177	0.516	.005	30	view →
HNSC	OS	Median	III,IV	0.558	0.695	.002	27	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	26	view →
MESO	OS	Tertile	All	0.499	0.290	.017	25	view →
LIHC	OS	Median	All	0.552	0.770	.010	25	view →
STAD	DFS	Tertile	IV	0.263	0.647	.017	24	view →
PCPG	DFS	Tertile	All	0.980	0.791	.002	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VAMP3–KIRC (DFS)

Open the KIRC breakdown →