UXT-AS1

Across TCGA pan-cancer cohorts, UXT-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UXT-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UXT-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types UXT-AS1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, STAD, and KIRP are the cancer types where UXT-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UXT-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.795	<.001	10	view →
STAD	All	All	+0.251	<.001	6	view →
KIRP	Male	All	−0.330	<.001	3	view →
LIHC	All	All	+0.198	.005	3	view →
HNSC	Male	IV	+0.284	.034	2	view →
LUAD	All	All	+0.141	.010	2	view →
LUSC	All	All	+0.129	.009	2	view →
BRCA	All	All	+0.092	.030	2	view →
COAD	Female	II,III,IV	+0.157	.031	1	view →
KIRC	Male	All	−0.112	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UXT-AS1–THCA

Open the THCA breakdown →