UTP6

Across TCGA patient cohorts, UTP6 mutation is significantly associated with the RNA expression of many other genes, with 3,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP6-associated genes across cancer lineages are MYCLP2, BPNT2P, and POLDIP3. Each is linked with UTP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both UTP6-to-partner and partner-to-UTP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYCLP2 grouped by UTP6-low versus UTP6-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP6→partner) and Y-score (partner→UTP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MYCLP2 →	+0.039	+4.925	<.001	.004	3	2
READ	BPNT2P →	+0.111	+5.681	<.001	.001	3	2
UCEC	POLDIP3 →	+0.564	+3.818	<.001	<.001	3	2
UCEC	AP1B1 →	+0.509	+3.938	<.001	<.001	3	2
UCEC	ASCC2 →	+0.235	+2.032	.008	.005	3	2
UCEC	PIGH →	+0.436	+3.711	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,106 associations by consensus.

MYCLP2 by UTP6 expression — READ

Explore this box plot interactively →