UTP6

Across TCGA patient cohorts, UTP6 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP6-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with UTP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UTP6-to-partner and partner-to-UTP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UTP6-low versus UTP6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP6→partner) and Y-score (partner→UTP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.441	-2.991	.009	.036	3	2
UCEC	eIF4E →	+0.165	+1.847	.033	.008	3	2
UCEC	FoxM1 →	+0.204	+1.847	.031	.008	3	2
UCEC	FOXO3a_pS318_S321 →	-0.125	-1.847	.006	.008	3	2
UCEC	Heregulin →	-0.105	-1.906	.020	.015	3	2
UCEC	MEK1 →	+0.506	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

EGFR_pY1068 by UTP6 expression — COAD

Explore this box plot interactively →