UTF1

Across TCGA patient cohorts, UTF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,982 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible UTF1-associated GO terms across cancer lineages are Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, Positive regulation of CD8-positive, alpha-beta T cell differentiation, and Regulation of leukocyte mediated cytotoxicity. Each is linked with UTF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both UTF1-to-partner and partner-to-UTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II grouped by UTF1-low versus UTF1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UTF1→partner) and Y-score (partner→UTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	+0.124	+0.147	<.001	<.001	3	20
ESCA	Positive regulation of CD8-positive, alpha-beta T cell differentiation →	+0.100	+0.149	<.001	<.001	3	19
STAD	Regulation of leukocyte mediated cytotoxicity →	+0.059	+0.148	<.001	<.001	3	18
STAD	Antigen processing and presentation of exogenous peptide antigen via MHC class II →	+0.127	+0.139	<.001	<.001	3	18
ESCA	Antigen processing and presentation of exogenous peptide antigen →	+0.090	+0.121	<.001	<.001	3	18
STAD	Regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	+0.122	+0.136	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,982 associations by consensus.

Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II by UTF1 expression — STAD

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