UTF1

Across TCGA cell cohorts, UTF1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UTF1-associated genes across cancer lineages are MAGEB4 and CYP2A13. Each is linked with UTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UTF1-to-partner and partner-to-UTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by UTF1-low versus UTF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTF1→partner) and Y-score (partner→UTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	CYP2A13 →	+0.029	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MAGEB4 by UTF1 expression — LARGE_INTESTINE

Explore this box plot interactively →