UST

Across TCGA cell cohorts, UST RNA expression is significantly associated with the go_rna of many other GO terms, with 3,955 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UST-associated GO terms across cancer lineages are Regulation of protein exit from endoplasmic reticulum, Negative regulation of organelle assembly, and Vesicle budding from membrane. Each is linked with UST in more than 7 cancer types. Because this analysis shows association rather than direction, both UST-to-partner and partner-to-UST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein exit from endoplasmic reticulum grouped by UST-low versus UST-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UST→partner) and Y-score (partner→UST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.113	+1.452	<.001	<.001	3	8
LIVER	Negative regulation of organelle assembly →	+0.079	+2.130	<.001	<.001	3	8
CNS	Vesicle budding from membrane →	+0.070	+1.168	<.001	<.001	3	7
BLOOD_Lymphoma	Aerobic electron transport chain →	+0.066	+1.331	.001	.005	3	7
BLOOD_Lymphoma	ATP synthesis coupled electron transport →	+0.068	+1.429	.001	.002	3	7
BLOOD_Lymphoma	Mitochondrial ATP synthesis coupled electron transport →	+0.068	+1.429	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,955 associations by consensus.

Regulation of protein exit from endoplasmic reticulum by UST expression — BONE

Explore this box plot interactively →