UST

Across TCGA pan-cancer cohorts, UST RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated UST data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UST RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UST expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

UCEC, ACC, and KIRP are the cancer types where UST RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.574	0.705	<.001	108	view →
ACC	DFS	Tertile	All	0.340	0.724	<.001	50	view →
KIRP	OS	Quartile	II,III,IV	0.592	0.920	.002	46	view →
LGG	DFS	Median	All	0.825	0.642	<.001	43	view →
LAML	DFS	Tertile	All	0.327	0.618	<.001	36	view →
HNSC	OS	Tertile	All	0.247	0.589	<.001	33	view →
COAD	DFS	Tertile	All	0.431	0.679	.006	26	view →
OV	OS	Median	III,IV	0.272	0.365	.005	20	view →
LIHC	DFS	Median	III,IV	0.606	0.217	<.001	20	view →
THCA	DFS	Median	All	0.904	0.779	.003	18	view →
GBM	DFS	Quartile	All	0.338	0.178	.006	18	view →
SCLC	OS	Tertile	All	0.524	0.216	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

UST–UCEC (DFS)

Open the UCEC breakdown →