UST

Across TCGA cell cohorts, UST mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UST-associated genes across cancer lineages are OR2B2, MRGPRG, and TMEM72. Each is linked with UST in more than 1 cancer types. Because this analysis shows association rather than direction, both UST-to-partner and partner-to-UST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B2 grouped by UST-low versus UST-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UST→partner) and Y-score (partner→UST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR2B2 →	+0.027	+3.684	<.001	.006	3	1
SKIN	MRGPRG →	+0.016	+4.437	<.001	.004	3	1
SKIN	TMEM72 →	+0.027	+4.269	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
LARGE_INTESTINE	FRG1 →	+0.548	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PSMD9 →	+0.494	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OR2B2 by UST expression — SKIN

Explore this box plot interactively →