Across TCGA pan-cancer cohorts, UST-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated UST-AS1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher UST-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UST-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and BLCA show a favorable association.

DLBC, ESCA, and BRCA are the cancer types where UST-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	IV	0.147	0.850	.002	78	view →
ESCA	DFS	Median	All	0.495	0.300	<.001	66	view →
BRCA	OS	Tertile	II,III,IV	0.918	0.964	.002	54	view →
HNSC	OS	Tertile	II,III,IV	0.356	0.645	.001	51	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
BLCA	OS	Tertile	All	0.546	0.393	.026	30	view →
LAML	DFS	Quartile	All	0.460	0.654	.020	26	view →
COAD	DFS	Tertile	II,III,IV	0.260	0.569	.016	24	view →
UCEC	DFS	Tertile	All	0.429	0.665	.010	24	view →
OV	DFS	Tertile	IV	0.725	0.412	.014	18	view →
UVM	OS	Tertile	All	1.000	0.525	.034	12	view →
KIRC	DFS	Tertile	All	0.445	0.644	.041	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

Exploration

Same gene, other analysis: UST-AS1 tumor-vs-normal RNA expression · all UST-AS1 data types