USP9X

Across TCGA patient cohorts, USP9X mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP9X-associated genes across cancer lineages are PCNA, ASNS, and Cyclin-E2. Each is linked with USP9X in more than 3 cancer types. Because this analysis shows association rather than direction, both USP9X-to-partner and partner-to-USP9X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by USP9X-low versus USP9X-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP9X→partner) and Y-score (partner→USP9X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.253	+2.128	.002	.009	3	4
COAD	ASNS →	+0.466	+1.423	<.001	.028	3	4
COAD	Cyclin-E2 →	+0.172	+3.321	.028	.009	3	4
COAD	Caspase-7-cleavedD198 →	+0.921	+2.717	<.001	.002	3	3
SKCM	Caveolin-1 →	-0.717	-3.169	.012	.017	3	3
COAD	eEF2 →	+0.294	+2.807	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PCNA by USP9X expression — COAD

Explore this box plot interactively →