USP9X

Across TCGA pan-cancer cohorts, USP9X RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP9X’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP9X RNA is repressed in tumor relative to normal tissue. In most cancer types USP9X is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, BRCA, and HNSC are the cancer types where USP9X tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP9X RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.492	<.001	8	view →
BRCA	All	II,III,IV	+0.270	<.001	6	view →
HNSC	All	All	+0.420	.005	5	view →
LUAD	All	All	+0.365	<.001	5	view →
STAD	All	II,III,IV	+0.642	.010	4	view →
LIHC	All	All	+0.378	.004	4	view →
LUSC	All	All	+0.302	.003	4	view →
ESCA	All	All	+0.669	.024	2	view →
UCEC	All	All	−0.572	.009	2	view →
BLCA	Female	All	+0.510	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP9X–THCA

Open the THCA breakdown →