USP9X

Across TCGA cell cohorts, USP9X mutation is significantly associated with the RNA expression of many other genes, with 745 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP9X-associated genes across cancer lineages are CACNA1S, S100G, and SCTR. Each is linked with USP9X in more than 1 cancer types. Because this analysis shows association rather than direction, both USP9X-to-partner and partner-to-USP9X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1S grouped by USP9X-low versus USP9X-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP9X→partner) and Y-score (partner→USP9X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CACNA1S →	+0.618	+3.807	<.001	.007	3	2
BREAST	S100G →	+0.375	+3.378	<.001	.006	3	2
BREAST	SCTR →	+0.264	+3.724	<.001	.004	3	2
BLOOD_Leukemia	KRT6C →	+0.008	+3.037	.006	.001	3	2
SKIN	OR1L3 →	+0.017	+4.000	<.001	<.001	3	2
LARGE_INTESTINE	ZBED4 →	+0.467	+3.307	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 745 associations by consensus.

CACNA1S by USP9X expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →