USP8

Across TCGA pan-cancer cohorts, USP8 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP8 data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher USP8 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated USP8 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, BRCA, and UCEC are the cancer types where USP8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	1.000	0.588	.001	26	view →
BRCA	OS	Median	All	0.166	0.579	<.001	24	view →
UCEC	DFS	Median	All	0.969	0.614	.004	22	view →
HNSC	DFS	Median	All	0.317	0.606	.016	8	view →
LUAD	OS	Median	III,IV	0.235	0.677	.030	3	view →
SKCM	DFS	Median	III,IV	0.119	0.654	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP8–BLCA (OS)

Open the BLCA breakdown →