USP8

Across TCGA pan-cancer cohorts, USP8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of USP8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP8 RNA is repressed in tumor relative to normal tissue. In most cancer types USP8 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where USP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.650	<.001	9	view →
HNSC	All	All	+0.326	.002	8	view →
LIHC	All	All	+0.444	<.001	7	view →
CHOL	All	All	+0.982	<.001	5	view →
LUAD	Female	II,III,IV	−0.476	.006	4	view →
STAD	All	II,III,IV	+0.420	.015	4	view →
READ	Female	All	−0.480	.007	2	view →
UCEC	All	All	−0.473	.018	2	view →
KICH	All	All	−0.456	.008	2	view →
BLCA	All	All	+0.301	.044	2	view →
COAD	All	All	−0.252	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

USP8–THCA

Open the THCA breakdown →