USP8

Across TCGA patient cohorts, USP8 protein abundance is significantly associated with the RNA expression of many other genes, with 17,652 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP8-associated genes across cancer lineages are IVD, NDUFAF1, and HAUS2. Each is linked with USP8 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP8-to-partner and partner-to-USP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP8 versus IVD in COAD, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP8→partner) and Y-score (partner→USP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IVD →	+0.643	+0.172	<.001	<.001	3	6
OV	NDUFAF1 →	+0.445	+0.204	<.001	.003	3	6
COAD	HAUS2 →	+0.473	+0.176	<.001	<.001	3	6
OV	TMOD3 →	+0.685	+0.244	<.001	<.001	3	6
COAD	SPPL2A →	+0.467	+0.155	<.001	<.001	3	6
BRCA	LEO1 →	+0.616	+0.282	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,652 associations by consensus.

USP8 vs IVD — COAD

Explore this scatter interactively →