USP8

Across TCGA patient cohorts, USP8 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP8-associated genes across cancer lineages are MEK1, AMPK_alpha, and ASNS. Each is linked with USP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP8-to-partner and partner-to-USP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by USP8-low versus USP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP8→partner) and Y-score (partner→USP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.388	+2.662	.001	<.001	3	2
UCEC	AMPK_alpha →	-0.127	-1.440	.039	.022	3	2
UCEC	ASNS →	+0.446	+1.765	<.001	.013	3	2
UCEC	ATM →	-0.413	-1.459	.004	.012	3	2
UCEC	4E-BP1 →	+0.267	+2.145	.002	.009	3	2
BLCA	14-3-3_zeta →	+0.240	+3.000	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MEK1 by USP8 expression — UCEC

Explore this box plot interactively →