USP8

Across TCGA cell cohorts, USP8 mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP8-associated genes across cancer lineages are OR11H6, CBY1, and GSR. Each is linked with USP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP8-to-partner and partner-to-USP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by USP8-low versus USP8-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP8→partner) and Y-score (partner→USP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OR11H6 →	+0.033	+3.977	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.661	+3.330	<.001	.002	3	1
LARGE_INTESTINE	GSR →	+0.754	+3.237	.006	.003	3	1
LARGE_INTESTINE	AGR2 →	+2.864	+3.067	.009	.009	3	1
LARGE_INTESTINE	TRIM37 →	+0.631	+3.502	.002	.001	3	1
LARGE_INTESTINE	PHF12 →	+0.580	+3.502	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

OR11H6 by USP8 expression — LIVER

Explore this box plot interactively →