USP8

Across TCGA cell cohorts, USP8 mutation is significantly associated with the mutation status of many other genes, with 6,618 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP8-associated genes across cancer lineages are NLRP2, STAB1, and ABCA2. Each is linked with USP8 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP8-to-partner and partner-to-USP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP2 grouped by USP8-low versus USP8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP8→partner) and Y-score (partner→USP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NLRP2 →	+5.502	+5.502	.003	.003	1	5
LARGE_INTESTINE	STAB1 →	+1.459	+3.862	<.001	<.001	1	5
LARGE_INTESTINE	ABCA2 →	+1.791	+2.769	<.001	<.001	1	5
BLOOD_Leukemia	PIK3C2A →	+4.309	+4.560	.007	.007	1	5
UPPER_AERODIGESTIVE_TRACT	ERCC6 →	+5.392	+5.392	.004	.004	1	5
BLOOD_Leukemia	TNRC6A →	+2.672	+4.225	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,618 associations by consensus.

NLRP2 by USP8 expression — SOFT_TISSUE

Explore this box plot interactively →