Across TCGA pan-cancer cohorts, USP7 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP7 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher USP7 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated USP7 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and LSCC are the cancer types where USP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.621	0.389	.004	15	view →
LUAD	DFS	Tertile	III,IV	0.993	0.311	.001	14	view →
LSCC	DFS	Quartile	All	0.906	0.611	.026	6	view →
PDAC	DFS	Tertile	All	0.499	0.257	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: USP7 tumor-vs-normal RNA expression · all USP7 data types