USP6NL

Across TCGA pan-cancer cohorts, USP6NL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP6NL data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP6NL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP6NL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where USP6NL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.868	0.650	.004	15	view →
UCEC	DFS	Quartile	All	1.000	0.803	.010	14	view →
LUAD	DFS	Median	III,IV	0.394	0.643	.023	5	view →
LSCC	OS	Quartile	All	0.557	0.827	.016	5	view →
PDAC	OS	Median	II,III,IV	0.899	0.764	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP6NL–CCRCC (DFS)

Open the CCRCC breakdown →