USP6NL

Across TCGA pan-cancer cohorts, USP6NL RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP6NL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where USP6NL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP6NL is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

COAD, BLCA, and KICH are the cancer types where USP6NL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP6NL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.877	<.001	10	view →
BLCA	All	III,IV	+0.790	.001	7	view →
KICH	Female	All	−0.923	<.001	6	view →
UCEC	All	All	+0.577	.005	6	view →
HNSC	All	II,III,IV	−0.537	.003	6	view →
CHOL	All	All	+0.877	.001	5	view →
READ	All	All	+0.707	.002	4	view →
KIRP	All	II,III,IV	+0.415	.012	4	view →
LUAD	All	IV	+0.594	.005	2	view →
PRAD	All	All	+0.275	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP6NL–COAD

Open the COAD breakdown →