USP6NL

Across TCGA patient cohorts, USP6NL mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP6NL-associated genes across cancer lineages are Notch1, 53BP1, and 14-3-3_beta. Each is linked with USP6NL in more than 2 cancer types. Because this analysis shows association rather than direction, both USP6NL-to-partner and partner-to-USP6NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by USP6NL-low versus USP6NL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP6NL→partner) and Y-score (partner→USP6NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.195	+1.938	<.001	.001	3	3
UCEC	53BP1 →	+0.272	+2.000	.015	.029	3	3
UCEC	14-3-3_beta →	-0.090	-2.673	.006	.005	3	2
UCEC	eIF4E →	+0.192	+2.598	.005	.005	3	2
UCEC	A-Raf_pS299 →	-0.155	-3.807	<.001	<.001	3	2
UCEC	FoxM1 →	+0.235	+1.652	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Notch1 by USP6NL expression — UCEC

Explore this box plot interactively →