USP6

Across TCGA patient cohorts, USP6 mutation is significantly associated with the RNA expression of many other genes, with 4,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP6-associated genes across cancer lineages are PIMREG, CTDNEP1, and HMG20B. Each is linked with USP6 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP6-to-partner and partner-to-USP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by USP6-low versus USP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP6→partner) and Y-score (partner→USP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.669	+1.536	<.001	<.001	3	4
UCEC	CTDNEP1 →	+0.236	+1.410	.001	<.001	3	4
UCEC	HMG20B →	+0.326	+2.091	<.001	<.001	3	4
UCEC	CINP →	+0.246	+2.732	<.001	<.001	3	3
LUAD	CORO2B →	-0.598	-3.561	.001	.002	3	3
UCEC	R3HCC1 →	+0.353	+1.971	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,487 associations by consensus.

PIMREG by USP6 expression — UCEC

Explore this box plot interactively →